Solid Dispersion Incorporated Fast Dissolving Oral Wafers of Cinnarizine: Development and Evaluation
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چکیده
منابع مشابه
Development of Fast Dissolving Sublingual Wafers of Promethazine Hydrochloride
Promethazine hydrochloride, a 5-HT3 antagonist is a powerful antiemetic drug with an oral bioavailability of 25% due to extensive hepatic first pass metabolism and is extremely bitter in taste. To overcome the above draw backs, the present study was carried out to formulate and evaluate fast dissolving taste masked wafers of Promethazine hydrochloride for sublingual administration. Taste maskin...
متن کاملdevelopment of fast dissolving sublingual wafers of promethazine hydrochloride
promethazine hydrochloride, a 5-ht3 antagonist is a powerful antiemetic drug with an oral bioavailability of 25% due to extensive hepatic first pass metabolism and is extremely bitter in taste. to overcome the above draw backs, the present study was carried out to formulate and evaluate fast dissolving taste masked wafers of promethazine hydrochloride for sublingual administration. taste maskin...
متن کاملFormulation and Evaluation of Mouth Dissolving Tablets of Cinnarizine
The purpose of this research was to develop mouth dissolve tablets of cinnarizine by effervescent, superdisintegrant addition and sublimation methods. All the three formulations were evaluated for disintegration time, hardness and friability, among these superdisintegrant addition method showed lowest disintegration time; hence it was selected for further studies. Further nine batches (B1-B9) w...
متن کاملIn Vitro-in Vivo Evaluation of Fast-dissolving Tablets Containing Solid Dispersion of Oxcarbazepine
Objective: Investigation of in vitro/in vivo behaviour of fast-dissolving tablets containing solid dispersions of oxcarbazepine is the focus of the present research work. Methods: The effect of various hydrophilic polymers on the aqueous solubility of oxcarbazepine was studied. Polyethylene glycol 6000 carrier was selected and solid dispersions were prepared by various methods. A total of nine ...
متن کاملCinnarizine Orodispersible Tablets: a Chitosan Based Fast Mouth Dissolving Technology
In recent days the use of fast mouth dissolving tablets are well accepted by elderly, children and the patients having trouble in swallowing and even by the travelling patients who find it convenient to ingest. Cinnarizine is a piperazine derivative and is widely prescribed for the treatment of vestibular disorders and motion sickness. To enhance the anti-emetic and anti-migraine properties of ...
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ژورنال
عنوان ژورنال: International Journal of Drug Delivery Technology
سال: 2018
ISSN: 0975-4415
DOI: 10.25258/ijddt.v8i01.11904